pentobarbital will decrease the level or effect of conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will lessen the level or outcome of dapsone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.Use Caution/Observe. CYP3A4 inducers may possibly